Prostate Cancer
– Prof. Donal Hollywood, Prof. Thomas Lynch, Prof. James Meaney

Prof. Donal HollywoodProfessor Donal Hollywood is Consultant Radiation Oncologist at St Luke’s and St James’s Hospitals in Dublin. He has a major interest in molecular oncology and his translational research studies include molecular and genetic analyses of prostate, breast, oesophageal and lung cancers. Prof. Hollywood’s prostate cancer studies are focused on the molecular optimisation of radiation response and the molecular biology of prostate cancer. He has published extensively on his research interests with additional contributions to a number of major textbooks including the Oxford Textbook of Oncology.

Prostate cancer is one of the most common cancers in men and causes more than 500 deaths every year in Ireland. It mainly affects men over the age of 65 and with an ageing population, figures worldwide are increasing. Treatment is potentially curative when the disease is found early. However, many more men die with prostate cancer than because of the disease.

Prof. Hollywoods study at CAMI is investigating a novel “triple-assessment” detection strategy, employing routine Prostate Specific Antigen (PSA) measurement, noninvasive genetic profiling of urine specimens and Magnetic Resonance Imaging (MRI). MRI is a powerful non-invasive detection method for prostate cancer.  Tumour neovasculature is associated with inhomogeneous blood flow, reduced oxygen tension and importantly is also a potential biomarker for treatment sensitivity.  Novel MRI approaches have been developed at CAMI to enable non-invasive assessment of tumour angiogenesis that correlates with elevated expression of angiogenesis markers in radical prostatectomy patients.

This study is an innovative multidisciplinary examination of noninvasive epigenetic profiling, together with tumour / hypoxia molecular imaging to improve current prostate cancer early detection strategies.